S-EPMC6975353 - Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study. - OmicsDI

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Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study.

ABSTRACT: BACKGROUND AND PURPOSE:Intracranial atherosclerosis, a major risk factor for ischemic stroke, is thought to have different atherogenic mechanisms than extracranial atherosclerosis. Studies investigating their relationship in vivo are sparse and report inconsistent results. We studied the relationship between intracranial atherosclerosis and extracranial atherosclerosis in a cohort of patients with a history of vascular disease. MATERIALS AND METHODS:Within the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART) study, cross-sectional analyses were performed in 130 patients (mean age, 68 ± 9?years) with a history of vascular disease and with assessable 7T intracranial vessel wall MR imaging data. Intracranial atherosclerosis burden was defined as the number of intracranial vessel wall lesions in the circle of Willis and its major branches. Age- and sex-adjusted unstandardized regression coefficients (b-value) were calculated with intracranial atherosclerosis burden as the dependent variable and extracranial atherosclerosis markers as independent variables. RESULTS:Ninety-six percent of patients had ?1 vessel wall lesion, with a mean intracranial atherosclerosis burden of 8.5 ± 5.7 lesions. Significant associations were observed between higher intracranial atherosclerosis burden and carotid intima-media thickness (b = 0.53 lesions per +0.1? mm; 95% CI, 0.1-1.0 lesions), 50%-100% carotid stenosis versus no stenosis (b = 6.6 lesions; 95% CI, 2.3-10.9 lesions), ankle-brachial index ? 0.9 versus >0.9 (b = 4.9 lesions; 95% CI, 1.7-8.0 lesions), and estimated glomerular filtration rate (b = -0.77 lesions per +10?mL/min; 95% CI, -1.50 to -0.03 lesions). No significant differences in intracranial atherosclerosis burden were found among different categories of vascular disease. CONCLUSIONS:Intracranial atherosclerosis was associated with various extracranial markers of atherosclerosis, not supporting a different etiology.

SUBMITTER: Zwartbol MHT

PROVIDER: S-EPMC6975353 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study.

Zwartbol M H T MHT Geerlings M I MI Ghaznawi R R Hendrikse J J van der Kolk A G AG

AJNR. American journal of neuroradiology 20191205 12

<h4>Background and purpose</h4>Intracranial atherosclerosis, a major risk factor for ischemic stroke, is thought to have different atherogenic mechanisms than extracranial atherosclerosis. Studies investigating their relationship in vivo are sparse and report inconsistent results. We studied the relationship between intracranial atherosclerosis and extracranial atherosclerosis in a cohort of patients with a history of vascular disease.<h4>Materials and methods</h4>Within the Second Manifestation ...[more]

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