Ontology highlight
ABSTRACT:
SUBMITTER: Xhima K
PROVIDER: S-EPMC6976301 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Xhima K K Markham-Coultes K K Nedev H H Heinen S S Saragovi H U HU Hynynen K K Aubert I I
Science advances 20200122 4
The degeneration of cholinergic neurons is a prominent feature of Alzheimer's disease (AD). In animal models of injury and aging, nerve growth factor (NGF) enhances cholinergic cell survival and function, contributing to improved memory. In the presence of AD pathology, however, NGF-related therapeutics have yet to fulfill their regenerative potential. We propose that stimulating the TrkA receptor, without p75<sup>NTR</sup> activation, is key for therapeutic efficacy. Supporting this hypothesis, ...[more]