Ontology highlight
ABSTRACT:
SUBMITTER: Matsui A
PROVIDER: S-EPMC6976731 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Matsui Ako A Kobayashi Junya J Kanno Shin-Ichiro SI Hashiguchi Kazunari K Miyaji Masahiro M Yoshikawa Yukihiro Y Yasui Akira A Zhang-Akiyama Qiu-Mei QM
Journal of radiation research 20200101 1
Human oxidation resistance 1 (OXR1) was identified as a protein that decreases genomic mutations in Escherichia coli caused by oxidative DNA damage. However, the mechanism by which OXR1 defends against genome instability has not been elucidated. To clarify how OXR1 maintains genome stability, the effects of OXR1-depletion on genome stability were investigated in OXR1-depleted HeLa cells using gamma-rays (γ-rays). The OXR1-depleted cells had higher levels of superoxide and micronucleus (MN) forma ...[more]