Identification of Potent VEGF Inhibitors for the Clinical Treatment of Glioblastoma, A Virtual Screening Approach.
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ABSTRACT:
SUBMITTER: Yadav M
PROVIDER: S-EPMC6976853 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Identification of Potent VEGF Inhibitors for the Clinical Treatment of Glioblastoma, A Virtual Screening Approach.
Yadav Mohini M Khandelwal Ravina R Mudgal Urvy U Srinitha Sivaraj S Khandekar Natasha N Nayarisseri Anuraj A Vuree Sugunakar S Singh Sanjeev Kumar SK
Asian Pacific journal of cancer prevention : APJCP 20190901 9
Vascular endothelial growth factor (VEGF) expression could be found in all glioblastomas. VEGF takes part in numerous changes including the endothelial cell proliferation, the vasculature of solid tumor: its survival invasion, and migration, chemotaxis of bone marrow-derived progenitor cells, vasodilation and vascular permeability. VEGF inhibition can be a smart therapeutic strategy because it is extremely specific and less toxic than cytotoxic therapy. To establish better inhibition of VEGF tha ...[more]
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