Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC9915956 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Chen Ying Y Chi Xiangyin X Zhang Hongjuan H Zhang Yu Y Qiao Luyao L Ding Jinwen J Han Yanxing Y Lin Yuan Y Jiang Jiandong J
International journal of molecular sciences 20230118 3
The Zika virus (ZIKV) epidemic poses a significant threat to human health globally. Thus, there is an urgent need for developing effective anti-ZIKV agents. ZIKV non-structural protein 5 RNA-dependent RNA polymerase (RdRp), a viral enzyme for viral replication, has been considered an attractive drug target. In this work, we screened an anti-infection compound library and a natural product library by virtual screening to identify potential candidates targeting RdRp. Then, five selected candidates ...[more]