Ontology highlight
ABSTRACT:
SUBMITTER: Card C
PROVIDER: S-EPMC6978462 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Card Catherine C Wilson David S DS Hirosue Sachiko S Rincon-Restrepo Marcela M de Titta Alexandre A Güç Esra E Martin Coralie C Bain Odile O Swartz Melody A MA Kilarski Witold W WW
Scientific reports 20200123 1
Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive immunity against a foreign, crosslinked protein, chicken egg ovalbumin (OVA), in the absence of an external adjuvant. The acylation of filarial proteins with fluorescent probes or biotin was not immediately detrimental to larval movement and su ...[more]