Unknown

Dataset Information

0

NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.


ABSTRACT: Activation of Agouti-Related Peptide (AgRP)-expressing neurons promotes feeding and insulin resistance. Here, we examine the contribution of neuropeptide Y (NPY)-dependent signaling to the diverse physiological consequences of activating AgRP neurons. NPY-deficient mice fail to rapidly increase food intake during the first hour of either chemo- or optogenetic activation of AgRP neurons, while the delayed increase in feeding is comparable between control and NPY-deficient mice. Acutely stimulating AgRP neurons fails to induce systemic insulin resistance in NPY-deficient mice, while increased locomotor activity upon AgRP neuron stimulation in the absence of food remains unaffected in these animals. Selective re-expression of NPY in AgRP neurons attenuates the reduced feeding response and reverses the protection from insulin resistance upon optogenetic activation of AgRP neurons in NPY-deficient mice. Collectively, these experiments reveal a pivotal role of NPY-dependent signaling in mediating the rapid feeding inducing effect and the acute glucose regulatory function governed by AgRP neurons.

SUBMITTER: Engstrom Ruud L 

PROVIDER: S-EPMC6978463 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.

Engström Ruud Linda L   Pereira Mafalda M A MMA   de Solis Alain J AJ   Fenselau Henning H   Brüning Jens C JC  

Nature communications 20200123 1


Activation of Agouti-Related Peptide (AgRP)-expressing neurons promotes feeding and insulin resistance. Here, we examine the contribution of neuropeptide Y (NPY)-dependent signaling to the diverse physiological consequences of activating AgRP neurons. NPY-deficient mice fail to rapidly increase food intake during the first hour of either chemo- or optogenetic activation of AgRP neurons, while the delayed increase in feeding is comparable between control and NPY-deficient mice. Acutely stimulatin  ...[more]

Similar Datasets

| S-EPMC6513552 | biostudies-literature
| S-EPMC6248907 | biostudies-literature
| S-EPMC4101536 | biostudies-literature
| S-EPMC3822903 | biostudies-literature
| S-EPMC9250019 | biostudies-literature
| S-EPMC3069789 | biostudies-literature
| S-EPMC8886056 | biostudies-literature
| S-EPMC10963273 | biostudies-literature
| S-EPMC6822260 | biostudies-literature
| S-EPMC4484787 | biostudies-literature