Ontology highlight
ABSTRACT:
SUBMITTER: Rey-Suarez I
PROVIDER: S-EPMC6978525 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Rey-Suarez Ivan I Wheatley Brittany A BA Koo Peter P Bhanja Anshuman A Shu Zhou Z Mochrie Simon S Song Wenxia W Shroff Hari H Upadhyaya Arpita A
Nature communications 20200123 1
Regulation of membrane receptor mobility tunes cellular response to external signals, such as in binding of B cell receptors (BCR) to antigen, which initiates signaling. However, whether BCR signaling is regulated by BCR mobility, and what factors mediate this regulation, are not well understood. Here we use single molecule imaging to examine BCR movement during signaling activation and a novel machine learning method to classify BCR trajectories into distinct diffusive states. Inhibition of act ...[more]