Unknown

Dataset Information

0

Emergence and Evolution of ERM Proteins and Merlin in Metazoans.


ABSTRACT: Ezrin, radixin, moesin, and merlin are cytoskeletal proteins, whose functions are specific to metazoans. They participate in cell cortex rearrangement, including cell-cell contact formation, and play an important role in cancer progression. Here, we have performed a comprehensive phylogenetic analysis of the proteins spanning 87 species. The results describe a possible mechanism for the protein family origin in the root of Metazoa, paralogs diversification in vertebrates, and acquisition of novel functions, including tumor suppression. In addition, a merlin paralog, present in most vertebrates but lost in mammals, has been described here for the first time. We have also highlighted a set of amino acid variations within the conserved motifs as the candidates for determining physiological differences between ERM paralogs.

SUBMITTER: Shabardina V 

PROVIDER: S-EPMC6978628 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6120716 | biostudies-literature
| S-EPMC5620054 | biostudies-literature
| S-EPMC4117225 | biostudies-literature
| S-EPMC6526912 | biostudies-literature
| S-EPMC4049578 | biostudies-literature
| S-EPMC1796844 | biostudies-literature
| S-EPMC4727409 | biostudies-literature
| S-EPMC5419745 | biostudies-literature
| S-EPMC2951704 | biostudies-literature
| S-EPMC3883804 | biostudies-other