Emergence and Evolution of ERM Proteins and Merlin in Metazoans.
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ABSTRACT:
SUBMITTER: Shabardina V
PROVIDER: S-EPMC6978628 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Emergence and Evolution of ERM Proteins and Merlin in Metazoans.
Shabardina Victoria V Kashima Yukie Y Suzuki Yutaka Y Makalowski Wojciech W
Genome biology and evolution 20200101 1
Ezrin, radixin, moesin, and merlin are cytoskeletal proteins, whose functions are specific to metazoans. They participate in cell cortex rearrangement, including cell-cell contact formation, and play an important role in cancer progression. Here, we have performed a comprehensive phylogenetic analysis of the proteins spanning 87 species. The results describe a possible mechanism for the protein family origin in the root of Metazoa, paralogs diversification in vertebrates, and acquisition of nove ...[more]
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