Ontology highlight
ABSTRACT:
SUBMITTER: Kraft VAN
PROVIDER: S-EPMC6978838 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kraft Vanessa A N VAN Bezjian Carla T CT Pfeiffer Susanne S Ringelstetter Larissa L Müller Constanze C Zandkarimi Fereshteh F Merl-Pham Juliane J Bao Xuanwen X Anastasov Natasa N Kössl Johanna J Brandner Stefanie S Daniels Jacob D JD Schmitt-Kopplin Philippe P Hauck Stefanie M SM Stockwell Brent R BR Hadian Kamyar K Schick Joel A JA
ACS central science 20191227 1
Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and glutathione levels to degenerative processes and tumor suppression. By performing a genome-wide activation screen, we identified a cohort of genes antagonizing ferroptotic cell death, including GTP cyclohydrolase-1 (GCH1) and its metabolic derivatives tetrahydrobiopterin/dihydrobiopterin (BH<sub>4</sub>/BH<sub>2</sub>). Synthesis of BH<sub>4</sub>/BH<sub>2</sub> by GCH1-expressing cells caused lipid remodeling ...[more]