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Clinical utility of estimation of glomerular filtration rate in dogs.


ABSTRACT: BACKGROUND:Glomerular filtration rate (GFR) estimation is the gold standard for assessment of renal function, although the clinical utility of this test is unclear. OBJECTIVES:To describe the clinical utility of GFR estimation in dogs. ANIMALS:Medical records of 132 dogs that had serum iohexol clearance measured between 2012 and 2017. METHODS:Iohexol clearance and clinical records were reviewed and submitting practices contacted to obtain outcome data. Dogs were classified into 4 groups based on the reason for performing GFR estimation: A1 (screening for pre-azotemic chronic kidney disease [CKD], n = 105), A2 (confirmation of azotemic CKD, n = 3), B (screening for pre-azotemic acute kidney injury, n = 19), and C (miscellaneous causes, n = 5). Descriptive review of the clinical utility of GFR estimation is provided. RESULTS:For dogs in Group A1, renal disease was diagnosed in 9/9 dogs with a GFR ?40% decreased below the mean GFR of their body weight category, in 5/6 dogs with a ?30% but <40% reduction in GFR and in 7/9 dogs with a ?20% but <30% reduction in GFR. CONCLUSIONS AND CLINICAL IMPORTANCE:Glomerular filtration rate estimation is useful for the diagnosis of CKD before the onset of azotemia.

SUBMITTER: McKenna M 

PROVIDER: S-EPMC6979109 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Clinical utility of estimation of glomerular filtration rate in dogs.

McKenna Myles M   Pelligand Ludovic L   Elliott Jonathan J   Walker David D   Jepson Rosanne R  

Journal of veterinary internal medicine 20190802 1


<h4>Background</h4>Glomerular filtration rate (GFR) estimation is the gold standard for assessment of renal function, although the clinical utility of this test is unclear.<h4>Objectives</h4>To describe the clinical utility of GFR estimation in dogs.<h4>Animals</h4>Medical records of 132 dogs that had serum iohexol clearance measured between 2012 and 2017.<h4>Methods</h4>Iohexol clearance and clinical records were reviewed and submitting practices contacted to obtain outcome data. Dogs were clas  ...[more]

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