Dataset Information

Association of Complement Factor D and H Polymorphisms with Recurrent Pregnancy Loss.

ABSTRACT: Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses prior to 20 weeks of gestation, and the incidence of RPL is estimated at 1% of all pregnancies. While the etiologies of RPL are diverse, immune function is considered to be an important cause of RPL. In particular, the complement system is essential for stable development of the placenta and fetus. Moreover, complement factor D (CFD) and complement factor H (CFH) are important regulators of the complement system and are associated with diseases, such as age-related macular degeneration. Therefore, we investigated whether polymorphisms of CFD and CFH are associated with RPL in 412 women with RPL and 384 control women. Genotyping of three polymorphisms (CFD rs2230216, CFH rs1065489, and CFH rs1061170) was performed by TaqMan probe real-time PCR and PCR-restriction fragment length polymorphism. Association of three polymorphisms with RPL was evaluated by statistical analysis. The GT/TC genotype combination of CFH rs1065489 G>T/CFH rs1061170 T>C was associated with a decreased risk of RPL occurrence compared with reference genotypes (adjusted odds ratio [AOR] = 0.439; 95% confidence interval [CI] = 0.238-0.810; p = 0.008), and this association remained significant after adjustment for multiple comparisons using false discovery rate (FDR) correction (p = 0.040). In addition, the CFH rs1065489G>T polymorphism is associated with homocysteine and prolactin level and CFH rs1061170 TC genotype is related to uric acid and triglycerides level in RPL patients. Therefore, those factors could be possible clinical risk factors in RPL patients.

SUBMITTER: Cho HY

PROVIDER: S-EPMC6981708 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Association of Complement Factor D and H Polymorphisms with Recurrent Pregnancy Loss.

Cho Hee Young HY Park Han Sung HS Ko Eun Ju EJ Ryu Chang Soo CS Kim Jung Oh JO Kim Young Ran YR Ahn Eun Hee EH Lee Woo Sik WS Kim Nam Keun NK

International journal of molecular sciences 20191218 1

Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses prior to 20 weeks of gestation, and the incidence of RPL is estimated at 1% of all pregnancies. While the etiologies of RPL are diverse, immune function is considered to be an important cause of RPL. In particular, the complement system is essential for stable development of the placenta and fetus. Moreover, complement factor D (<i>CFD</i>) and complement factor H (<i>CFH</i>) are important regulators of the co ...[more]

PMID: 31861421

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Project description:Background:Multiple studies have been carried out examining the association of tumor necrosis factor-? gene (TNF-?) promoter region polymorphisms with recurrent pregnancy loss (RPL) risk. However, the results remain controversial and incomplete. Hence, we performed a meta-analysis to evaluate the association of the TNF-? -308G>A and -238G>A polymorphisms with RPL risk. Materials and Methods:In this meta-analysis, a comprehensive search of PubMed, Web of Knowledge and EMBASE was performed to identify relevant studies published until December 1, 2017. The associations were assessed by odds ratio (OR) and its corresponding 95% confidence interval (CI). Results:A total of 29 case-control studies, comprising 20 studies on TNF-? -308G>A (3,461 cases and 3,895 controls) and nine studies on TNF-? -238G>A (2,589 cases and 2,664 controls), were included in the meta-analysis. Overall, we found TNF-? -308G>A to be associated with an increase in RPL risk under the homozygote (OR=1.716, 95% CI: 1.210-2.433, P=0.002) and the recessive (OR=1.554, 95% CI: 1.100-2.196, P=0.012) models. TNF-? -238G>A was also significantly associated with increased risk of RPL under the allele model (OR=1.554, 95% CI: 1.100-2.196, P=0.012). Stratified analysis revealed a more significant association between theTNF-? -308G>A polymorphism and increased RPL risk in Asians under the homozygote (OR=2.190, 95% CI: 1.465-3.274, P?0.001), the dominant (OR=1.642, 95% CI: 1.269-2.125, P?0.001) and the recessive (OR=1.456, 95% CI: 1.039-2.040, P=0.029) models, but not in Caucasians. A non-significant association was, however, identified between TNF-? -238G>A and RPL risk based on ethnicity. Moreover, TNF-? -308G>A and -238G>A polymorphisms were significantly associated with increased risk of RPL in high quality studies and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) subgroups. Conclusion:The present meta-analysis demonstrates that TNF-? -308G>A and -238G>A polymorphisms are associated with an increased risk of RPL.

Dataset Information

Association of Complement Factor D and H Polymorphisms with Recurrent Pregnancy Loss.

Publications

Association of Complement Factor D and H Polymorphisms with Recurrent Pregnancy Loss.

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