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Association of TNF-? genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis.

ABSTRACT: Several studies on the association of tumor necrosis factor alpha (TNF-?) polymorphisms with recurrent pregnancy loss (RPL) risk have reported conflicting results. The present meta-analysis was conducted to provide a more precise estimation of these relationships and to investigate the real association between TNF-? polymorphisms and RPL.An extensive eligible literature search for relevant studies was conducted on PubMed, Embase, and The Cochrane Library from their inceptions to May 12, 2015. Specific inclusion criteria were used to evaluate articles. The odds ratio (OR) with 95% confidence intervals (CIs) were used to assess the strength of associations. Statistical analyses were performed by the STATA12.0 software.10 case-control studies including 1430 RPL patients and 1727 healthy controls were identified. Meta-analysis indicated that TNF-?-308G/A (rs1800629) polymorphism in the TNF-? gene correlated with elevated RPL risk whereas no significant association was observed between TNF-?-238G/A (rs361625) and RPL.The current meta-analysis demonstrates that TNF-?-308G/A polymorphism in the TNF-? gene is associated with susceptibility to RPL.

SUBMITTER: Li HH

PROVIDER: S-EPMC4736635 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis.

Li Hui-Hui HH Xu Xing-Hua XH Tong Jing J Zhang Kai-Yue KY Zhang Cong C Chen Zi-Jiang ZJ

Reproductive biology and endocrinology : RB&E 20160202

<h4>Background</h4>Several studies on the association of tumor necrosis factor alpha (TNF-α) polymorphisms with recurrent pregnancy loss (RPL) risk have reported conflicting results. The present meta-analysis was conducted to provide a more precise estimation of these relationships and to investigate the real association between TNF-α polymorphisms and RPL.<h4>Methods</h4>An extensive eligible literature search for relevant studies was conducted on PubMed, Embase, and The Cochrane Library from t ...[more]

PMID: 26837816

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Project description:Background:Multiple studies have been carried out examining the association of tumor necrosis factor-? gene (TNF-?) promoter region polymorphisms with recurrent pregnancy loss (RPL) risk. However, the results remain controversial and incomplete. Hence, we performed a meta-analysis to evaluate the association of the TNF-? -308G>A and -238G>A polymorphisms with RPL risk. Materials and Methods:In this meta-analysis, a comprehensive search of PubMed, Web of Knowledge and EMBASE was performed to identify relevant studies published until December 1, 2017. The associations were assessed by odds ratio (OR) and its corresponding 95% confidence interval (CI). Results:A total of 29 case-control studies, comprising 20 studies on TNF-? -308G>A (3,461 cases and 3,895 controls) and nine studies on TNF-? -238G>A (2,589 cases and 2,664 controls), were included in the meta-analysis. Overall, we found TNF-? -308G>A to be associated with an increase in RPL risk under the homozygote (OR=1.716, 95% CI: 1.210-2.433, P=0.002) and the recessive (OR=1.554, 95% CI: 1.100-2.196, P=0.012) models. TNF-? -238G>A was also significantly associated with increased risk of RPL under the allele model (OR=1.554, 95% CI: 1.100-2.196, P=0.012). Stratified analysis revealed a more significant association between theTNF-? -308G>A polymorphism and increased RPL risk in Asians under the homozygote (OR=2.190, 95% CI: 1.465-3.274, P?0.001), the dominant (OR=1.642, 95% CI: 1.269-2.125, P?0.001) and the recessive (OR=1.456, 95% CI: 1.039-2.040, P=0.029) models, but not in Caucasians. A non-significant association was, however, identified between TNF-? -238G>A and RPL risk based on ethnicity. Moreover, TNF-? -308G>A and -238G>A polymorphisms were significantly associated with increased risk of RPL in high quality studies and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) subgroups. Conclusion:The present meta-analysis demonstrates that TNF-? -308G>A and -238G>A polymorphisms are associated with an increased risk of RPL.

Dataset Information

Association of TNF-? genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis.

Publications

Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis.

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