Ontology highlight
ABSTRACT:
SUBMITTER: Haidar S
PROVIDER: S-EPMC6982966 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20191226 1
Casein kinase II (CK2) is an intensively studied enzyme, involved in different diseases, cancer in particular. Different scaffolds were used to develop inhibitors of this enzyme. Here, we report on the synthesis and biological evaluation of twenty phenolic, ketonic, and <i>para</i>-quinonic indeno[1,2-<i>b</i>]indole derivatives as CK2 inhibitors. The most active compounds were 5-isopropyl-1-methyl-5,6,7,8-tetrahydroindeno[1,2-<i>b</i>]indole-9,10-dione <b>4h</b> and 1,3-dibromo-5-isopropyl-5,6, ...[more]