Ontology highlight
ABSTRACT:
SUBMITTER: Liko D
PROVIDER: S-EPMC6983401 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Liko Dritan D Rzepiela Andrzej A Vukojevic Vanja V Zavolan Mihaela M Hall Michael N MN
Proceedings of the National Academy of Sciences of the United States of America 20200109 3
Loss of the tumor suppressor tuberous sclerosis complex 1 (<i>Tsc1</i>) in the liver promotes gluconeogenesis and glucose intolerance. We asked whether this could be attributed to aberrant expression of small RNAs. We performed small-RNA sequencing on liver of <i>Tsc1</i>-knockout mice, and found that miRNAs of the delta-like homolog 1 (<i>Dlk1</i>)-deiodinase iodothyronine type III (<i>Dio3</i>) locus are up-regulated in an mTORC1-dependent manner. Sustained mTORC1 signaling during development ...[more]