Ontology highlight
ABSTRACT:
SUBMITTER: Tong KC
PROVIDER: S-EPMC6983449 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20200102 3
Cysteine thiols of many cancer-associated proteins are attractive targets of anticancer agents. Herein, we unequivocally demonstrate a distinct thiol-targeting property of gold(III) mesoporphyrin IX dimethyl ester (AuMesoIX) and its anticancer activities. While the binding of cysteine thiols with metal complexes usually occurs via M-S bond formation, AuMesoIX is unique in that the <i>meso</i>-carbon atom of the porphyrin ring is activated by the gold(III) ion to undergo nucleophilic aromatic sub ...[more]