Radiation Therapy in Patients With Brain Cancer: Post-proteomics Interpretation.

ABSTRACT: Introduction: Radiation therapy (RT) as a common method for cancer treatment could result in some side effects. The molecular investigation is one of the approaches that could assist in decrypting the molecular mechanisms of this incident. For this aim, protein-protein interaction (PPI) network analysis as a complementary study of the proteome is conducted to explore the RT effect on brain cancer after the early stage of exposure prior to the appearance of the skin lesion. Methods: Cytoscape 3.7.2 and its plug-ins were used to analyze the network of differential expression of proteins (DEPs) in the treatment condition, and the centrality and pathway enrichment was conducted by the use of NetworkAnalyzer and ClueGO+CluePedia. Results: A network of 15 DEPs indicated that 6 nodes were key pla

SUBMITTER: Asadzadeh-Aghdaei H 

PROVIDER: S-EPMC6983876 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature