Ontology highlight
ABSTRACT:
SUBMITTER: Levin SD
PROVIDER: S-EPMC6985287 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Levin Steven D SD Evans Lawrence S LS Bort Susan S Rickel Erika E Lewis Katherine E KE Wu Rebecca P RP Hoover Joseph J MacNeil Sean S La David D Wolfson Martin F MF Rixon Mark W MW Dillon Stacey R SR Kornacker Michael G MG Swanson Ryan R Peng Stanford L SL
Frontiers in immunology 20200121
Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases. We have developed a directed evolution platform capable of engineering IgSF domains to increase affinities for cognate ligands and/or introduce binding to non-cognate ligands. Using this scientific platform, ICOSL domains have been derived with enha ...[more]