Ontology highlight
ABSTRACT:
SUBMITTER: Zhou H
PROVIDER: S-EPMC6985330 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhou Hefeng H Shao Min M Guo Baojian B Li Chuwen C Lu Yucong Y Yang Xuanjun X ShengnanLi Li Haitao H Zhu Qi Q Zhong Hanbing H Wang Yuqiang Y Zhang Zaijun Z Lu Jiahong J Lee Simon Ming-Yuen SM
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20191001 4
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and is characterized in part by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). The main pathological hallmark of PD is the intraneuronal accumulation of misfolded α-synuclein (α-syn) aggregates. Mutations in the SNCA gene (encoding α-syn) and variations in its copy number are associated with some forms of familial PD. In the present study, T-006, a new tetramethylpyrazin ...[more]