Ontology highlight
ABSTRACT:
SUBMITTER: Jiang D
PROVIDER: S-EPMC6986426 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cell 20191219 1
Voltage-gated sodium channel Na<sub>v</sub>1.5 generates cardiac action potentials and initiates the heartbeat. Here, we report structures of Na<sub>V</sub>1.5 at 3.2-3.5 Å resolution. Na<sub>V</sub>1.5 is distinguished from other sodium channels by a unique glycosyl moiety and loss of disulfide-bonding capability at the Na<sub>V</sub>β subunit-interaction sites. The antiarrhythmic drug flecainide specifically targets the central cavity of the pore. The voltage sensors are partially activated, a ...[more]