Ontology highlight
ABSTRACT:
SUBMITTER: Sanor LD
PROVIDER: S-EPMC6986871 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Sanor Lucas D LD Flowers Grant Parker GP Crews Craig M CM
eLife 20200128
Axolotls and other salamanders can regenerate entire limbs after amputation as adults, and much recent effort has sought to identify the molecular programs controlling this process. While targeted mutagenesis approaches like CRISPR/Cas9 now permit gene-level investigation of these mechanisms, genetic screening in the axolotl requires an extensive commitment of time and space. Previously, we quantified CRISPR/Cas9-generated mutations in the limbs of mosaic mutant axolotls before and after regener ...[more]