Ontology highlight
ABSTRACT:
SUBMITTER: Messias CV
PROVIDER: S-EPMC6987159 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20200128 1
Previous work showed that the thymus can be infected by RNA viruses as HIV and HTLV-1. We thus hypothesized that the thymus might also be infected by the Zika virus (ZIKV). Herein we provide compelling evidence that ZIKV targets human thymic epithelial cells (TEC) in vivo and in vitro. ZIKV-infection enhances keratinization of TEC, with a decrease in proliferation and increase in cell death. Moreover, ZIKV modulates a high amount of coding RNAs with upregulation of genes related to cell adhesion ...[more]