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Design, synthesis and application of a new type of bifunctional Le-Phos in highly enantioselective ?-addition reactions of N-centered nucleophiles to allenoates.

ABSTRACT: A novel class of cyclic phosphine derived bifunctional catalysts (Le-Phos) is reported, which can be readily prepared from inexpensive and commercially available starting materials and exhibit good performances in enantioselective ?-addition reactions of N-centered nucleophiles and allenoates under mild conditions. The salient features of this reaction include high product yields, good enantioselectivity, mild reaction conditions, and broad substrate scope and gram-scale scalability.

SUBMITTER: Qiu H

PROVIDER: S-EPMC6988743 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Design, synthesis and application of a new type of bifunctional Le-Phos in highly enantioselective γ-addition reactions of N-centered nucleophiles to allenoates.

Qiu Haile H Chen Xiaofeng X Zhang Junliang J

Chemical science 20190903 45

A novel class of cyclic phosphine derived bifunctional catalysts (Le-Phos) is reported, which can be readily prepared from inexpensive and commercially available starting materials and exhibit good performances in enantioselective γ-addition reactions of N-centered nucleophiles and allenoates under mild conditions. The salient features of this reaction include high product yields, good enantioselectivity, mild reaction conditions, and broad substrate scope and gram-scale scalability. ...[more]

PMID: 32055374

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