Ontology highlight
ABSTRACT:
SUBMITTER: Akmammedov A
PROVIDER: S-EPMC6988889 | biostudies-literature | 2019 Mar - Dec
REPOSITORIES: biostudies-literature
Akmammedov Arslan A Geigges Marco M Paro Renato R
Fly 20190301 1-4
Polycomb group (PcG) and Trithorax group (TrxG) proteins orchestrate development of a multicellular organism by faithfully maintaining cell fate decisions made early in embryogenesis. An important chromatin mark connected to PcG/TrxG regulation is bivalent domains, the simultaneous presence of H3K27me3 and H3K4me3 on a given locus, originally identified in mammalian embryonic stem cells but considered to be absent in invertebrates. Here, we provide evidence for the existence of bivalency in fly ...[more]