Genome mining for lasso peptides: past, present, and future.
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ABSTRACT:
SUBMITTER: Cheung-Lee WL
PROVIDER: S-EPMC6989040 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Genome mining for lasso peptides: past, present, and future.
Cheung-Lee Wai Ling WL Link A James AJ
Journal of industrial microbiology & biotechnology 20190605 9-10
Over the course of roughly a decade, the lasso peptide field has been transformed. Whereas new compounds were discovered infrequently via activity-driven approaches, now, the vast majority of lasso peptide discovery is driven by genome-mining approaches. This paper starts with a historical overview of the first genome-mining approaches for lasso peptide discovery, and then covers new tools that have emerged. Several examples of novel lasso peptides that have been discovered via genome mining are ...[more]
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