The Role of Maintenance Strategies in Metastatic Colorectal Cancer: A Systematic Review and Network Meta-analysis of Randomized Clinical Trials.

ABSTRACT:

Importance

In metastatic colorectal cancer, induction combination chemotherapy with a targeted agent is considered the mainstay of treatment. Multiple randomized clinical trials have examined different strategies of continuing cytotoxic therapy until progression compared with a period of either observation or the use of various maintenance agents. However, those randomized clinical trials have shown inconsistent efficacy results that make it challenging to draw any conclusion on which strategy is preferred. Therefore, a network meta-analysis is helpful to compare different agents across randomized clinical trials.

Objective

To evaluate the comparative effectiveness of different treatment strategies for patients with metastatic colorectal cancer.

Evidence review

MEDLIN

SUBMITTER: Sonbol MB 

PROVIDER: S-EPMC6990730 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature