Neurodegenerative diseases as proteinopathies-driven immune disorders.
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ABSTRACT:
SUBMITTER: Ciccocioppo F
PROVIDER: S-EPMC6990794 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Neurodegenerative diseases as proteinopathies-driven immune disorders.
Ciccocioppo Fausta F Bologna Giuseppina G Ercolino Eva E Pierdomenico Laura L Simeone Pasquale P Lanuti Paola P Pieragostino Damiana D Del Boccio Piero P Marchisio Marco M Miscia Sebastiano S
Neural regeneration research 20200501 5
In the pathophysiology of neurodegenerative disorders, the role of misfolded protein deposition leading to neurodegeneration has been primarily discussed. In the last decade, however, it has been proposed a parallel involvement of innate immune activation, chronic inflammation and adaptive immunity in the neurodegeneration mechanisms triggered by proteinopathies. New insights in the neurodegenerative field strongly suggest a role for the immune system in the pathophysiology of neurodegenerative ...[more]
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