Ontology highlight
ABSTRACT:
SUBMITTER: Llorens F
PROVIDER: S-EPMC6992814 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Llorens Franc F Hermann Peter P Villar-Piqué Anna A Diaz-Lucena Daniela D Nägga Katarina K Hansson Oskar O Santana Isabel I Schmitz Matthias M Schmidt Christian C Varges Daniela D Goebel Stefan S Dumurgier Julien J Zetterberg Henrik H Blennow Kaj K Paquet Claire C Baldeiras Inês I Ferrer Isidro I Zerr Inga I
Nature communications 20200130 1
The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimer's disease (AD), other neurodegene ...[more]