Ontology highlight
ABSTRACT:
SUBMITTER: Dohner K
PROVIDER: S-EPMC6993016 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Döhner Konstanze K Thiede Christian C Jahn Nikolaus N Panina Ekaterina E Gambietz Agnes A Larson Richard A RA Prior Thomas W TW Marcucci Guido G Jones Dan D Krauter Jürgen J Heuser Michael M Voso Maria Teresa MT Ottone Tiziana T Nomdedeu Josep F JF Mandrekar Sumithra J SJ Klisovic Rebecca B RB Wei Andrew H AH Sierra Jorge J Sanz Miguel A MA Brandwein Joseph M JM de Witte Theo T Jansen Joop H JH Niederwieser Dietger D Appelbaum Frederick R FR Medeiros Bruno C BC Tallman Martin S MS Schlenk Richard F RF Ganser Arnold A Serve Hubert H Ehninger Gerhard G Amadori Sergio S Gathmann Insa I Benner Axel A Pallaud Celine C Stone Richard M RM Döhner Hartmut H Bloomfield Clara D CD
Blood 20200101 5
Patients with acute myeloid leukemia (AML) harboring FLT3 internal tandem duplications (ITDs) have poor outcomes, in particular AML with a high (≥0.5) mutant/wild-type allelic ratio (AR). The 2017 European LeukemiaNet (ELN) recommendations defined 4 distinct FLT3-ITD genotypes based on the ITD AR and the NPM1 mutational status. In this retrospective exploratory study, we investigated the prognostic and predictive impact of the NPM1/FLT3-ITD genotypes categorized according to the 2017 ELN risk gr ...[more]