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Impact of a low FODMAP diet on the amount of rectal gas and rectal volume during radiotherapy in patients with prostate cancer - a prospective pilot study.


ABSTRACT: BACKGROUND:Small inter- and intrafractional prostate motion was shown to be a prerequisite for precise radiotherapy (RT) of prostate cancer (PCa) to achieve good local control and low rectal toxicity. As rectal gas and rectal volume are known to have a relevant effect on prostate motion, this study aims to reduce these parameters by using a Low FODMAP Diet (LFD) and to show feasibility of this intervention. METHODS:We compared a prospective intervention group (IG, n?=?25) which underwent RT for PCa and whose patients were asked to follow a LFD during RT with a retrospective control group (CG, n?=?25) which did not get any dietary advice. In the planning CT scan and all available cone beam CT scans rectal gas was classified based on a semiquantitative score (scale from 1 to 5) and rectal volume was measured. Furthermore, patients' compliance was evaluated by a self-assessment questionnaire. RESULTS:Clinical and treatment characteristics were well balanced between both groups. A total of 266 (CG, 10.6 per patient) and 280 CT scans (IG, 11.2 per patient), respectively, were analysed. The frequency distribution of gas scores differed significantly from each other (p?

SUBMITTER: Schaefer C 

PROVIDER: S-EPMC6993432 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Impact of a low FODMAP diet on the amount of rectal gas and rectal volume during radiotherapy in patients with prostate cancer - a prospective pilot study.

Schaefer Christian C   Zamboglou Constantinos C   Volegova-Neher Natalja N   Martini Carmen C   Nicolay Nils Henrik NH   Schmidt-Hegemann Nina-Sophie NS   Rogowski Paul P   Li Minglun M   Belka Claus C   Müller Arndt-Christian AC   Grosu Anca-Ligia AL   Brunner Thomas T  

Radiation oncology (London, England) 20200130 1


<h4>Background</h4>Small inter- and intrafractional prostate motion was shown to be a prerequisite for precise radiotherapy (RT) of prostate cancer (PCa) to achieve good local control and low rectal toxicity. As rectal gas and rectal volume are known to have a relevant effect on prostate motion, this study aims to reduce these parameters by using a Low FODMAP Diet (LFD) and to show feasibility of this intervention.<h4>Methods</h4>We compared a prospective intervention group (IG, n = 25) which un  ...[more]

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