Ontology highlight
ABSTRACT:
SUBMITTER: Saleh NM
PROVIDER: S-EPMC6993756 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in chemistry 20200124
EGFR and VEGFR-2 represent promising targets for cancer treatment as they are very important in tumor development as well as in angiogenesis and metastasis. In this work, 6-amino-4-(2-bromophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile <b>1</b> and (E)-4-(2-Bromobenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one <b>11</b> were selected as starting materials to synthesize different fused pyrazole derivatives; dihydropyrano[2,3-c]pyrazole <b>1</b>, <b>2</b>, <b>7</b>-<b>9</b>, an ...[more]