Ontology highlight
ABSTRACT:
SUBMITTER: Le P
PROVIDER: S-EPMC6994260 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Le Philipp P Kunold Elena E Macsics Robert R Rox Katharina K Jennings Megan C MC Ugur Ilke I Reinecke Maria M Chaves-Moreno Diego D Hackl Mathias W MW Fetzer Christian C Mandl Franziska A M FAM Lehmann Johannes J Korotkov Vadim S VS Hacker Stephan M SM Kuster Bernhard B Antes Iris I Pieper Dietmar H DH Rohde Manfred M Wuest William M WM Medina Eva E Sieber Stephan A SA
Nature chemistry 20191216 2
New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sorafenib as major hit that effectively kills MRSA strains. Varying the key structural features led to the identification of a potent analogue, PK150, that showed antibacterial activity against several pathogenic strains at submicromolar concentrations. Furthermore, this antibiotic ...[more]