Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD, Q Exactive
ORGANISM(S): Staphylococcus Aureus
SUBMITTER: Philipp Le
LAB HEAD: Stephan A. Sieber
PROVIDER: PXD012946 | Pride | 2019-09-09
REPOSITORIES: pride
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Nature chemistry 20191216 2
New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sorafenib as major hit that effectively kills MRSA strains. Varying the key structural features led to the identification of a potent analogue, PK150, that showed antibacterial activity against several pathogenic strains at submicromolar concentrations. Furthermore, this antibiotic ...[more]