Ontology highlight
ABSTRACT:
SUBMITTER: Foinquinos A
PROVIDER: S-EPMC6994493 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature communications 20200131 1
Despite proven efficacy of pharmacotherapies targeting primarily global neurohormonal dysregulation, heart failure (HF) is a growing pandemic with increasing burden. Treatments mechanistically focusing at the cardiomyocyte level are lacking. MicroRNAs (miRNA) are transcriptional regulators and essential drivers of disease progression. We previously demonstrated that miR-132 is both necessary and sufficient to drive the pathological cardiomyocytes growth, a hallmark of adverse cardiac remodelling ...[more]