Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz-Cordero R
PROVIDER: S-EPMC6995064 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ruiz-Cordero Roberto R Ma Junsheng J Khanna Abha A Lyons Genevieve G Rinsurongkawong Waree W Bassett Roland R Guo Ming M Routbort Mark J MJ Zhang Jianjun J Skoulidis Ferdinandos F Heymach John J Roarty Emily B EB Tang Zhenya Z Medeiros L Jeffrey LJ Patel Keyur P KP Luthra Rajyalakshmi R Roy-Chowdhuri Sinchita S
BMC cancer 20200131 1
<h4>Background</h4>Gene expression profiling has consistently identified three molecular subtypes of lung adenocarcinoma that have prognostic implications. To facilitate stratification of patients with this disease into similar molecular subtypes, we developed and validated a simple, mutually exclusive classification.<h4>Methods</h4>Mutational status of EGFR, KRAS, and TP53 was used to define seven mutually exclusive molecular subtypes. A development cohort of 283 cytology specimens of lung aden ...[more]