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Unravelling the means to an end: RNA polymerase II transcription termination.

ABSTRACT: The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II (Pol II)-mediated transcription, and termination of its activity is necessary to partition the genome and maintain the proper expression of neighbouring genes. Despite its ever-increasing biological significance, transcription termination remains one of the least understood processes in gene expression. However, recent mechanistic studies have revealed a striking convergence among several overlapping models of termination, including the poly(A)- and Sen1-dependent pathways, as well as new insights into the specificity of Pol II termination among its diverse gene targets. Broader knowledge of the role of Pol II carboxy-terminal domain phosphorylation in promoting alternative mechanisms of termination has also been gained.

SUBMITTER: Kuehner JN

PROVIDER: S-EPMC6995273 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Unravelling the means to an end: RNA polymerase II transcription termination.

Kuehner Jason N JN Pearson Erika L EL Moore Claire C

Nature reviews. Molecular cell biology 20110413 5

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II (Pol II)-mediated transcription, and termination of its activity is necessary to partition the genome and maintain the proper expression of neighbouring genes. Despite its ever-increasing biological significance, transcription termination remains one of the least understood processes in gene expression. However, recent mechanistic studies have revealed a striking convergence among several overlapping mode ...[more]

PMID: 21487437

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