Allele-specific imbalance mapping at human orthologs of mouse susceptibility to colon cancer (Scc) loci.

ABSTRACT: Colorectal cancer (CRC) can be classified into different types. Chromosomal instable (CIN) colon cancers are thought to be the most common type of colon cancer. The risk of developing a CIN-related CRC is due in part to inherited risk factors. Genome-wide association studies have yielded over 40 single nucleotide polymorphisms (SNPs) associated with CRC risk, but these only account for a subset of risk alleles. Some of this missing heritability may be due to gene-gene interactions. We developed a strategy to identify interacting candidate genes/loci for CRC risk that utilizes both linkage and RNA-seq data from mouse models in combination with allele-specific imbalance (ASI) studies in human tumors. We applied our strategy to three previously identified CRC susceptibility loci in the mouse

SUBMITTER: Gerber MM 

PROVIDER: S-EPMC6995280 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature