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Serum ferritin and obstructive sleep apnea-epidemiological study.

ABSTRACT: PURPOSE:Ferritin is an intracellular iron storage protein and a marker of inflammation. Studies have shown that subjects with obstructive sleep apnea (OSA) have higher levels of circulating pro-inflammatory cytokines, but little is known about the association between ferritin and OSA. The aims of the study were to evaluate serum ferritin (S-Ferritin) levels in OSA patients compared to levels in the general population and also examine the effect of obesity level and treatment with positive airway pressure (PAP) on S-Ferritin levels. METHODS:The OSA subjects (n?=?796) were part of the Icelandic Sleep Apnea Cohort. The control subjects (n?=?637) were randomly chosen Icelanders who participated in an epidemiological study. Propensity score (PS) methodologies were employed to minimize selection bias and strengthen causal inferences when comparing non-randomized groups. S-Ferritin levels were measured and all participants answered the same detailed questionnaire about sleep and health. Only OSA patients underwent a sleep study and were re-invited for a 2-year follow-up. RESULTS:S-Ferritin levels were significantly higher in OSA males than controls (213.3 vs. 197.3 ?g/L, p?=?0.007). However, after adjusting for confounders and using our PS methodology, no significant difference was found. S-Ferritin levels were not correlated with severity of OSA, obesity level, or clinical symptoms. Also, no significant change in S-Ferritin levels was found with 2 years of PAP treatment. CONCLUSIONS:S-Ferritin levels are comparable in OSA patients and controls and do not change consistently with obesity level or PAP treatment in our sample.

SUBMITTER: Thorarinsdottir EH

PROVIDER: S-EPMC6996026 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Serum ferritin and obstructive sleep apnea-epidemiological study.

Thorarinsdottir Elin H EH Arnardottir Erna S ES Benediktsdottir Bryndis B Janson Christer C Olafsson Isleifur I Pack Allan I AI Gislason Thorarinn T Keenan Brendan T BT

Sleep & breathing = Schlaf & Atmung 20171209 3

<h4>Purpose</h4>Ferritin is an intracellular iron storage protein and a marker of inflammation. Studies have shown that subjects with obstructive sleep apnea (OSA) have higher levels of circulating pro-inflammatory cytokines, but little is known about the association between ferritin and OSA. The aims of the study were to evaluate serum ferritin (S-Ferritin) levels in OSA patients compared to levels in the general population and also examine the effect of obesity level and treatment with positiv ...[more]

PMID: 29224135

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Project description:BackgroundPeriostin is a matricellular protein and is a useful marker in respiratory diseases. However, the roles of periostin in patients with obstructive sleep apnea (OSA) remain unclear. Several in vitro studies have suggested that mechanical stress, hypoxia, impaired metabolism, and kidney injury, which often accompany OSA, may upregulate the expression of periostin. Meanwhile, serum periostin level has been negatively associated with body mass index (BMI) in the general population. In this study, we hypothesized that a high level of serum periostin despite being overweight/obese may discriminate severe OSA or OSA with comorbidities from mild OSA with obesity alone. We aimed to clarify the roles of periostin in patients with OSA to assist in elucidating the heterogeneity of OSA with comorbidities.MethodsAmong patients diagnosed as OSA, we examined the associations between serum periostin levels and clinical indices, including the severity of OSA, BMI, and comorbidities, using a multifaceted approach. The serum periostin levels and clinical indices were assessed after 3?months of continuous positive airway pressure (CPAP) treatment.ResultsIn 96 patients with OSA, serum periostin level was negatively correlated with BMI, albeit marginally, and tended to be higher in severe OSA than in others when adjusted for BMI. Cluster analysis identified four clusters, including two severe OSA clusters, one of which was characterized by high serum periostin levels and the presence of comorbidities, including albuminuria. In a comparative analysis of severe OSA cases (n?=?53), the level of serum-free fatty acids and the frequency of albuminuria were higher in patients with high serum periostin level of ?87?ng/mL, which was the highest quintile among all participants, than in those with low serum periostin levels (<?87?ng/mL, n?=?41). In patients with severe OSA and high serum periostin levels, the levels of serum periostin and urinary albumin significantly decreased after 3?months of CPAP treatment.ConclusionsElevated serum periostin in patients with OSA despite being overweight/obese may be an indicator of severe OSA with comorbidities, particularly albuminuria.

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Serum ferritin and obstructive sleep apnea-epidemiological study.

Publications

Serum ferritin and obstructive sleep apnea-epidemiological study.

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