NF-kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol.
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SUBMITTER: Oda-Kawashima K
PROVIDER: S-EPMC6996339 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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NF-kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol.
Oda-Kawashima Keiko K Sedukhina Anna S AS Okamoto Naoki N Lytvyn Mariya M Minagawa Kimino K Iwata Teppei T Kumai Toshio T Sato Eri E Inada Eiichi E Yamaura Ayako A Sakamoto Miki M Roche-Molina Marta M Bernal Juan A JA Sato Ko K
FEBS open bio 20200115 2
Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in myocardial remodeling is unknown. Here, we performed in silico analysis to investigate signaling alterations in cardiomyocytes induced by inhalational [sevoflurane (Sevo)] and intravenous [propofol (Prop)] anesthetics. Bioinformatics analysis revealed that nuclear factor-kappa B (NF-kB) signaling was inhibited by Sevo and promoted by Prop. Moreover, nucl ...[more]
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