Transcriptomics

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Gene expression of brain regions activated by sevoflurane and propofol


ABSTRACT: The basic mechanisms of action for general anesthesia are not fully understood. We thought differences in the neural activation sites of different types of anesthetics and differences in gene expression changes in those brain regions may lead to differences in the incidence of side effects. We performed gene expression analysis using microarrays in the identified regions that have been related to the mechanisms of anesthetic action and side effects. Gene expression changes in these brain regions were determined for sevoflurane and propofol to understand the mechanisms that cause differences among anesthetics.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE192399 | GEO | 2021/12/22

REPOSITORIES: GEO

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