Ontology highlight
ABSTRACT:
SUBMITTER: Tsunematsu T
PROVIDER: S-EPMC6996931 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Tsunematsu Tomomi T Patel Amisha A AA Onken Arno A Sakata Shuzo S
eLife 20200114
The brainstem plays a crucial role in sleep-wake regulation. However, the ensemble dynamics underlying sleep regulation remain poorly understood. Here, we show slow, state-predictive brainstem ensemble dynamics and state-dependent interactions between the brainstem and the hippocampus in mice. On a timescale of seconds to minutes, brainstem populations can predict pupil dilation and vigilance states and exhibit longer prediction power than hippocampal CA1 neurons. On a timescale of sub-seconds, ...[more]