Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC7000153 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Li Liangji L Rozo Michelle M Yue Sibiao S Zheng Xiaobin X J Tan Frederick F Lepper Christoph C Fan Chen-Ming CM
Nature metabolism 20190930 10
Muscle undergoes progressive weakening and regenerative dysfunction with age due in part to the functional decline of skeletal muscle stem cells (MuSCs). MuSCs are heterogeneous but whether their gene expression changes with age and the implication of such changes are unclear. Here we show that in mice, Growth arrest-specific gene 1 (Gas1) is expressed in a small subset of young MuSCs with its expression progressively increasing in larger fractions of MuSCs later in life. Over-expression of Gas1 ...[more]