Ontology highlight
ABSTRACT:
SUBMITTER: Wan Z
PROVIDER: S-EPMC7000777 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Wan Zurong Z Shao Xingxing X Ji Xingyu X Dong Lihui L Wei Jiacheng J Xiong Zhuqing Z Liu Wanli W Qi Hai H
Cellular & molecular immunology 20181206 2
The B7-family inducible costimulator (ICOS) activates phosphoinositide-3 kinase (PI3K) and augments calcium mobilization triggered by the T-cell receptor (TCR). We surprisingly found that the entire cytoplasmic domain of ICOS is dispensable for its costimulation of calcium mobilization. This costimulatory function relies on the unique transmembrane domain (TMD) of ICOS, which promotes association with the tyrosine kinase Lck. TMD-enabled Lck association is also required for p85 recruitment to IC ...[more]