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Advances toward Curing HIV-1 Infection in Tissue Reservoirs.

ABSTRACT: A disease of more than 39.6 million people worldwide, HIV-1 infection has no curative therapy. To date, one man has achieved a sterile cure, with millions more hoping to avoid the potential pitfalls of lifelong antiretroviral therapy and other HIV-related disorders, including neurocognitive decline. Recent developments in immunotherapies and gene therapies provide renewed hope in advancing efforts toward a sterilizing or functional cure. On the horizon is research concentrated in multiple separate but potentially complementary domains: vaccine research, viral transcript editing, T-cell effector response targeting including checkpoint inhibitors, and gene editing. Here, we review the concept of targeting the HIV-1 tissue reservoirs, with an emphasis on the central nervous system, and describe relevant new work in functional cure research and strategies for HIV-1 eradication.

SUBMITTER: Henderson LJ

PROVIDER: S-EPMC7000960 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Advances toward Curing HIV-1 Infection in Tissue Reservoirs.

Henderson Lisa J LJ Reoma Lauren B LB Kovacs Joseph A JA Nath Avindra A

Journal of virology 20200117 3

A disease of more than 39.6 million people worldwide, HIV-1 infection has no curative therapy. To date, one man has achieved a sterile cure, with millions more hoping to avoid the potential pitfalls of lifelong antiretroviral therapy and other HIV-related disorders, including neurocognitive decline. Recent developments in immunotherapies and gene therapies provide renewed hope in advancing efforts toward a sterilizing or functional cure. On the horizon is research concentrated in multiple separa ...[more]

PMID: 31694954

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