Dataset Information

Elastase-triggered H₂S delivery from polymer hydrogels.

ABSTRACT: We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels.

SUBMITTER: Zhou M

PROVIDER: S-EPMC7001589 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Elastase-triggered H<sub>2</sub>S delivery from polymer hydrogels.

Zhou Mingjun M Qian Yun Y Zhu Yumeng Y Matson John J

Chemical communications (Cambridge, England) 20200101 7

We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels. ...[more]

PMID: 31894779

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Project description:Foams made with polymer hydrogels can be used in a variety of applications, such as scaffolds for biomedical applications or decontamination processes. However, from a practical point of view, it is difficult to introduce bubbles into viscous or viscoelastic fluids and to produce large volumes of hydrogel foams. In the present article, we investigate the foaming process of poly(vinyl alcohol) (PVA)/borax transient hydrogels, where PVA chains reversibly bind to borax molecules. In a previous article, we showed that foams obtained with PVA/borax mixtures are highly stable because of both high interfacial and bulk viscosities and can be used to quickly absorb liquids, which make them suitable for detergency or decontamination processes. To produce these foams, we use a two-step foaming process which consists in first shearing a PVA solution to obtain a PVA foam and second adding borax to the PVA foam under continuous shearing. The obtained PVA/borax foams are stable for weeks. In this study, we observe a shear-induced collapse of the foams for formulations containing a low borax/PVA ratio, whereas they remain stable under shear for high PVA/borax ratios. Using scaling arguments, we find that the shear-induced collapse of the foams and bubbles is obtained below a critical ratio, N E/N B = 15, of the number of entanglements per chain, N E, and the number of borax per chain, N B. Rheology measurements show that the samples present a shear-thickening behavior that increases with the borax concentration. We suggest that during the foaming process when the shearing rate is of the order of 100 s-1, the viscosity of these samples diverges, leading to a viscous to fragile transition. To mimic the fast stretching of the PVA/borax thin films during the foaming process, we study the stretching of individual PVA/borax catenoid-shaped thin films at high stretching rates. We observe that the films containing low PVA/borax ratios do not minimize their surface area unlike what is theoretically expected for standard surfactant films. Moreover, the films tend to be unstable and fracture because the PVA/borax network does not have time to rearrange and relax stresses for high stretching rates.

Dataset Information

Elastase-triggered H₂S delivery from polymer hydrogels.

Publications

Elastase-triggered H<sub>2</sub>S delivery from polymer hydrogels.

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Dataset Information

Elastase-triggered H2S delivery from polymer hydrogels.

Publications

Elastase-triggered H<sub>2</sub>S delivery from polymer hydrogels.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Elastase-triggered H₂S delivery from polymer hydrogels.