Elastase-triggered H2S delivery from polymer hydrogels.
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ABSTRACT:
SUBMITTER: Zhou M
PROVIDER: S-EPMC7001589 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Elastase-triggered H<sub>2</sub>S delivery from polymer hydrogels.
Zhou Mingjun M Qian Yun Y Zhu Yumeng Y Matson John J
Chemical communications (Cambridge, England) 20200101 7
We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels. ...[more]
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