Ontology highlight
ABSTRACT:
SUBMITTER: Murphy SK
PROVIDER: S-EPMC7001679 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20170601 6341
The tricyclic diterpene fungal metabolite (+)-pleuromutilin has served as a starting point for antibiotic development. Semisynthetic modification of its glycolic acid subunit at C14 provided the first analogs fit for human use, and derivatization at C12 led to 12-<i>epi</i>-pleuromutilins with extended-spectrum antibacterial activity, including activity against Gram-negative pathogens. Given the inherent limitations of semisynthesis, however, accessing derivatives of (+)-pleuromutilin with full ...[more]