Ontology highlight
ABSTRACT:
SUBMITTER: Urbitsch F
PROVIDER: S-EPMC7146891 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Urbitsch Felix F Elbert Bryony L BL Llaveria Josep J Streatfeild Penelope E PE Anderson Edward A EA
Organic letters 20200207 4
Resolvins D3 and E1 are important signaling molecules in the resolution of inflammation. Here, we report a convergent and flexible strategy to prepare these natural products using Hiyama-Denmark coupling of five- and six-membered cyclic alkenylsiloxanes to connect three resolvin fragments, and control the stereochemistry of the natural product (<i>Z</i>)-alkenes. The modular nature of this approach enables the synthesis of novel resolvin hybrids, opening up opportunities for more-extensive inves ...[more]