Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen AW
PROVIDER: S-EPMC7002138 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nguyen Annalee W AW DiVenere Andrea M AM Papin James F JF Connelly Sheila S Kaleko Michael M Maynard Jennifer A JA
Science advances 20200205 6
Pertussis continues to cause considerable infant mortality world-wide, which could be addressed in part by passive immunization strategies. Antibody hu1B7 is a candidate therapeutic that potently neutralizes pertussis toxin in vitro, prevents leukocytosis in mice and treats established disease in weanling baboons as part of an antibody cocktail. Here, we evaluated the potential for hu1B7 and an extended half-life hu1B7 variant to prevent death, leukocytosis and other clinical symptoms in a newbo ...[more]