Ontology highlight
ABSTRACT:
SUBMITTER: Deardorff DR
PROVIDER: S-EPMC7003507 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
ACS omega 20200123 4
The enantioselective syntheses of (-)-coniine, DAB-1, and nectrisine have been developed, utilizing a complementary strategy of enzyme- and transition metal-catalyzed reactions. The initial stereocenter was set with >99% enantioselectivity via an enzyme-catalyzed hydrocyanation reaction. Substrate incompatibilities with the natural enzyme were overcome by tactical utilization of ruthenium-catalyzed olefin metathesis to functionalize an enzyme-derived (<i>R</i>)-allylic fragment. The piperidine a ...[more]