Ontology highlight
ABSTRACT:
SUBMITTER: Sehin Y
PROVIDER: S-EPMC7003650 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Sehin Yuliia Y Koshla Oksana O Dacyuk Yuriy Y Zhao Ruoxia R Ross Robert R Myronovskyi Maksym M Limbach Patrick A PA Luzhetskyy Andriy A Walker Suzanne S Fedorenko Victor V Ostash Bohdan B
Microbiology (Reading, England) 20181213 2
Streptomyces ghanaensis ATCC14672 is remarkable for its production of phosphoglycolipid compounds, moenomycins, which serve as a blueprint for the development of a novel class of antibiotics based on inhibition of peptidoglycan glycosyltransferases. Here we employed mariner transposon (Tn) mutagenesis to find new regulatory genes essential for moenomycin production. We generated a library of 3000 mutants which were screened for altered antibiotic activity. Our focus centred on a single mutant, H ...[more]